2 Georgia vs. No. ET. The LSU Tigers snuck into the AP Top 25 to be ranked for the first time under Brian Kelly. Here are our picks straight up and against the spread for Week 6 . No. Top college football predictions for Week 3. 24 Cincinnati vs. South Florida , 2:30 p.m. ET: UConn-Vanderbilt was on ESPNU this past weekend, and it actually ended up producing one of the most entertaining fourth quarters of the day, ending on a game-winning field goal for the Commodores at the buzzer. Clemson is fresh off a bye week headed to South Bend to play the Notre Dame Fighting Irish, who have finally found some life. The former 4-star recruit from the class of 2018 started his career at Michigan. ET. If the turnover margin in this one ends up being a wash, I like Penn State to get the road win, as I have substantially more faith in the Nittany Lions offense in a battle of field position. Mississippi State, meanwhile, has won two straight over Bowling Green and Texas A&M. 19 Kansas vs. No. Indiana's season is nothing short of unusual. ET, ESPN3), No. Both SEC West contenders are in desperate need of a bounce-back game if they want to remain in the hunt for a division crown. 15 Wake Forest (-15) (7:30 p.m. Running back Brad Roberts is the leader for the Falcons, recording 13 touchdowns and 943 yards this season. ET, San Jose State (3-2) at Colorado State (1-3), 3:30 p.m. Circa Sports reopened its conference future odds ahead of Week 6 with six different ACC teams at 8-to-1 or less to win the title Clemson at +180 (risking $1 to win 41.80), Pittsburgh at +470 . ET: Coastal Carolina at UL Monroe, 8 p.m. Ole Miss trailed Alabama 35-0 before making the final score (42-21) a little bit more respectable. ET, Buffalo (2-3) at Kent State (2-3), 7 p.m. We will have 6 Premium Picks against the spread this week! As a senior at Junipero Serra High School last season, Murphy threw for 2,973 yards. ET, ESPNU), Texas A&M at No. 18 UCLA vs. No. Luckily for Georgia, the Dawgs play at home against an Auburn team that is struggling. But Oklahoma has held each of its five opponents to 100 rushing yards or fewer. ESPN's College GameDay will be in town for the first time ever, so the atmosphere in Lawrence, Kansas should be electric. The Tennessee Volunteers are averaging 49.4 points and 553 yards this season, taking down teams like Alabama, Florida and LSU. And though the preseason Heisman favorite hasn't been anywhere near as proficient as expected, we've got to go with Spencer Rattler over Casey Thompson if this boils down to which quarterback has the most fourth-quarter heroics up his sleeve. It was 24-0 in a heartbeat, 45-6 by halftime and 52-6 early in the third when Buckeyes coach Ryan Day decided to fill the field with backups. The saving grace for LSU is that Kentucky doesn't have a ball-hawking defense (three turnovers forced through five games) and the Wildcats haven't been particularly potent on offense as of late either. Iowa at No. Notre Dame has back-to-back wins, defeating Syracuse and UNLV. ET, East Carolina (3-2) at UCF (2-2), 6 p.m. ET. Prediction:Arizona State 35, Stanford 17, No. Making matters even more fun, meteorologists are calling for rain across Virginia pretty much all week, so this could be quite the slop fest. 17 Ole Miss (3-1) vs. No. And I like the Razorbacks to pull off the road upset. The Tar Heels are steamrolling through the ACC, with four straight conference wins. Still, a fight for the top four will get even tougher in the next few weeks. 20 UCLA all lost to unranked foes. Given how great both of these defenses have beenonly Georgia (4.6 points allowed per game) has a better scoring defense than Iowa (11.6) and Penn State (12.0)a similar result seems likely. 10 Florida, No. While the spotlight has been pointed toward the offense, Tulane's defense has allowed only 17.4 points per game. 3 Oregon. Rock chalk! This will be the toughest defense UCLA has faced this season, as the Utes rank 12th in scoring defense, allowing just 14.4 points per game. James Madison at Arkansas State, 7 p.m. Florida (vs. Missouri) 12 p.m. Aside from its loss to Utah, Oregon State has been a legit team the entire season. There are three matchups this weekend pitting top 25 ranked teams on . In the exception to that rule, though, Texas scored 70 and ran all over the Red Raiders, so it wouldn't be much of a surprise if Zach Evans has a field day for TCU. ET: Nevada 24, Colorado State 10, UNLV at San Jos State, 10:30 p.m. The Aggies suffered a shocking upset at home to Appalachian State in Week 2, and lost 42-24 to Mississippi State last week. The Trojans shouldn't have too much trouble against Washington State. The major factor for this matchup is the Bulldogs defense giving Georgia the better overall talent edge, since Tennessee has had trouble against the pass this season. He has added another 255 yards and three scores on the ground, too. This will be the definition of a run-heavy game, with Tucker and Pittsburgh running back Israel Abanikanda going jab for jab. But I think Martinez can make some plays with his feet late in this one to win it close. Although Florida State has lost the last two to NC State, I like the 'Noles in an upset here. The Bearcats aren't making noise as a playoff contender this season, thanks to their loss to Arkansas in Week 1. LSU could put up a fight for a half, but the Tigers seem to be a year or two away from competing in games with Top 10 teams under Kelly. Maybe the Knights will boot and rally to knock off Michigan State for a second consecutive year, but I can't pick it. No. 17 Ole Miss covers as a six-point favorite against No. 1 Georgia facing off against No. This just seems like a trap game for the Wildcats. However, the first Friday night Pac-12 game of the season tends to be a wild one, so we'll see what actually happens. They will continue their hot streak and defeat the Tigers at home. The Tigers barely beat Missouri in Week 4, needing overtime to win 17-14. ET, CBS), Texas Tech at No. It looks like Saturday will bring the steak to six. After failing to find the end zone all game, the Dawgs finally scored two touchdowns in the fourth quarter to win 26-22. The Buckeyes haven't lost a game this season, and they'll be playing a team that's allowed over 30 points in three straight games. The Bruins will be playing in Tempe, which should bring a bigger crowd than they are used to, but those fans will trickle out when the Bruins lead a couple of big-play drives. 17 Ole Miss (3-1), Noon ET. I just don't think it will be enough to make up for the difficulty Ole Miss is likely to have with an Arkansas rushing attack that has been potent against teams not named Georgia. In the last three weeks, he's combined for seven passing touchdowns and five scores on the ground. 8 Tennessee, Noon ETSee No. No. ET: Fresno State 28, Hawai'i 14. 8). One of the biggest stories of this season has been high-scoring offenses, which is a common story for teams in the Top 10. It looks like Ducks quarterback Bo Nix is feeling comfortable in Dan Lanning's offense. ET kickoff on Saturday. ET: South Carolina 34, Vanderbilt 23, JMU at Louisville, 7:30 p.m. Use the Matchup generator below to analyze all games. Ronald Martinez/Getty Images, Bijan Robinson. The wait is finally over. The Volunteers head to Athens, Georgia, where both teams will compete to hand each other their first loss of the season. No. The Cyclones lost 31-24 against Baylor before falling 14-11 at Kansas last week. 117: Central Michigan Chippewas 30.2. NCAA football predictions and Week 6 Opening Line Report with Best Bets and Picks by expert college football handicappers at Docsports.com. This prime-time clash in Blacksburg fits the bill for Week 6. Enjoy the free college football picks against the spread as well! Despite starting quarterback Chance Nolan (concussion protocol) being out for multiple games, the Beavers are on a three-game winning streak. Unfortunately, quarterback Spencer Sanders has been digressing each week throughout the season so far. 18 Auburn (4-1), 3:30 p.m. Kansas will play host to College GameDay for the first time in program history as it attempts to go to 6-0 . . But that's a best-case scenario in which a nothing-special run defense manages to hold Chris Rodriguez Jr. and Co. below 200 rushing yards, which I don't see happening. Rick Ulreich/Icon Sportswire via Getty Images, Do Not Sell or Share My Personal Information. This would've been a more favorable matchup for ND if the Tigers didn't have two weeks to get back to the drawing board. The Week 6 slate begins on Wednesday night with SMU taking . No. TCU might be the sneakiest undefeated team in the country with an electric offense that's averaging 44.3 points per game. ET, ABC), Washington State at No. Tennessee still has to go to Louisiana and win, but the circumstances around the game are as ideal as they can be for a visiting team, especially one that does not go to Tiger Stadium on a regular basis. ET, Fox), South Carolina at No. Arizona's poor defense that gives up 475 yards per game won't be able to stop the Utes. 25 San Diego State (4-0) vs. New Mexico (2-3), 9 p.m. Kansas State looks like one of the best teams in the Big 12, having upset Oklahoma 41-34 and beating Texas Tech 37-28 in back-to-back weeks. AZ/CO/CT/IL/IN/IA/LA/MI/NH/NJ/NY/OR/PA/TN/VA/WV/WY only. ET. 24 SMU (5-0) at Navy (1-3), 3:30 p.m. 2 Georgia (5-0) at No. One of Sallee's top college football picks for Week 6: He's predicting that Clemson (-20.5) will take care of business and cover the three-score spread at Boston College in a 7:30 p.m. ET. In the last three weeks, CJ Stroud and the Buckeyes' offense have put up an average of 59 points. Chip Kelly's UCLA Bruins surged into the rankings after Week 5 as well. ET, Old Dominion (1-4) at Marshall (2-3), 2 p.m. 2 Georgia (-29.5) (3:30 p.m. This won't be a close one, at all. So there's no better time for predictions. Texas Tech, meanwhile, started the season 2-0, but have dropped two out of its last three against NC State and Kansas State. ET: Middle Tennessee 21, Louisiana Tech 13, Washington State at Stanford, 3:30 p.m. The Tigers blew a 17-0 lead last week to LSU, and had four turnovers to lose 21-17. Georgia State enjoyed an out-of-nowhere offensive surge in a 46-14 Week 5 win over UL Monroe, but the Panthers should come crashing back . Penn State is undefeated, but the Nittany Lions have yet to play a ranked team yet on their schedule. 3 Iowa. 13 Arkansas.The . The Volunteers play inside Tiger Stadium for an early afternoon kickoff, which is not an ideal time slot for a visiting team. The South Dakota State Jackrabbits and North Dakota State Bison face off on Sunday in the college football. Statistically Generated Predictions for all Week 6 Matchups. Top college football predictions for Week 9. They needed to make a winning impact, and although the month of October was a difficult stretch for the Noles (1-3 record), they appear to be on the right path. Awesome if you enjoy low-scoring, late drama, that is. He doesn't put up fancy numbers or many Heisman-level performances, but the Wolverines live through their success on the ground, and a team like Rutgers won't have an answer for that. Cincy's offense, which ranks 18th nationally in scoring (40.2 ppg), should have no problems against a USF defense that is tied at 122nd in scoring defense. One of the college picks the model is high on in Week 9: No. In fact, the Hogs' last four opponents have been held without a single passing touchdown and limited to 105.5 passing yards on average. 3 Oregon, No. The Huskies offense is incredibly underrated, averaging over 40 points and 500 yards per game. It's always a toss-up in a night game at Carter-Finley Stadium, but matchups like this usually favor the more experienced team. 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